Health Benefits of Bioactive Compounds Found in Garlic, Onions, Leeks, Chives, Scallions, and Shallots

allium bioactive compounds

Breast cancer is the most frequently diagnosed type of cancer in women in the United States. Ductal carcinoma is an early stage, localized form of breast cancer that can progress to an invasive breast cancer and increase the lifelong risk of developing a metastatic and lethal breast cancer. The survival of patients with ductal carcinoma depends on blocking the progression of ductal carcinoma lesions to an invasive form of breast cancer.

Currently there are no effective chemo-preventive strategies to prevent the development of breast ductal carcinoma. Studies of how often diseases occur in different groups of people have suggested an inverse association between consumption of Allium vegetables (e.g., garlic and onions) and a lower risk of developing cancer, including breast cancer.

Diallyl trisulfide is a bioactive compound found naturally in Allium vegetables, that has been shown to have multiple anticancer effects. This project is working to develop a novel strategy to target the growth and progression of ductal carcinoma by using diallyl trisulfide. Providing a proof-of-principle for the effect of diallyl trisulfide against ductal carcinoma. The long term goal of this project is to develop a novel chemo-preventive strategy for breast cancer that uses diet-derived bioactive compounds.